Grape seed extract is used as an antioxidant, to prevent coronary heart disease (CHD), stroke, and to strengthen capillaries and improve circulation to the extremities.
Grape seed extract is often used to treat conditions associated with vascular function such as diabetes mellitus, varicose veins, impotence, and tingling in the arms and legs.
Proanthocyanidins are believed to have the following effects:
- Antioxidant: neutralizing free radicals, blocking lipid peroxidation and stabilizing cell membranes.
- Inhibit the destruction of collagen by stabilizing the activity of 1-antitrypsin. 1-antitrypsin inhibits the actions of destructive enzymes.
- Inhibit the release of histamine and prostaglandins.
- Inhibit platelet aggregation.