Common Name Ginseng
Latin Binomial Panax ginseng C.A. Meyer
Family: Araliaceae
Part used Root. White ginseng represents the peeled and sun-dried root, while red ginseng is unpeeled, steamed, and dried. (1)
Active Constituents Triterpenes:
  • Ginsenoside Rb1
  • Ginsenoside Rb2
  • Ginsenoside Rc
  • Ginsenoside Rd
  • Ginsenoside Re
  • Ginsenoside Rf
  • Ginsenoside Rg
Side Effects Investigation of safety for well characterized ginseng root preparations are needed. However, the available evidence suggests that preparations of ginseng root are well tolerated when used for limited periods of time at recommended doses. (1)
In high doses, insomnia, nervous excitability, euphoria, nausea, and diarrhea may occur. (46)
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Herbal Use/Indication Ginseng is stated to possess thymoleptic sedative, demulcent, and stomachic properties, and is reputed to be an aphrodisiac. (1)
Traditionally, ginseng has been used for neurasthenia, neuralgia, insomnia, hypertonia, and specifically for depressive states associated with sexual inadequacy. (16)(19)(64)(29)
Ginseng is used as a stimulant, tonic, diuretic, and stomachic.
(43)
Short term use in healthy individuals include: to improve stamina, concentration, healing, stress resistance, and work efficacy. For longer term use, ginseng is used to improve well-being in debilitated and degenerative conditions associated with old age. (1)
Pharmacological Actions Ginsenosides may augment adrenal steroidogenesis via an indirect action on the pituitary gland. (44)Hormones produced by the pituitary and adrenal glands are known to play a significant role in the adaptive capabilities of the body. (47)
Many of the pharmacological actions directly oppose one another. This has been attributed to the actions of the individual ginsenosides. For example, Rb1 exhibits CNS depressant, hypotensive, and tranquillising actions. Rg exhibits stimulative, hypertensive, and anti-fatiguing actions. These opposing actions are though to explain the adaptogenic reputation of ginseng. Adaptogenic is the ability to increase the overall resistance of the body to stress and balance bodily functions. (1)
Contra-Indications Ginseng preparations are contra-indicated during acute illness, hemorrhage, and during an acute period of coronary thrombosis. (1)
Ginseng root should be avoided by individuals who are highly energetic, nervous, tense, hysteric, manic, or schizophrenic. Ginseng should not be taken with stimulants (coffee), anti psychotic drugs, or during treatment with hormones. (1)
Ginseng root should be used with caution in patients with diabetes and cardiovascular disorders. It is appropriate to advise against long-term or excessive use. (1)
Drug-Interactions
Should not be taken with anticoagulant, hypoglycemic, or cardiovascular medications. (1)
Pregnancy or lactation
The safety of ginseng root has not been established in humans and therefore should be avoided during pregnancy and lactation.
Summary Clinical trials of ginseng preparations have focused on the adaptogenic properties. At present there is insufficient evidence to support definitely the efficacy of specific Panax species preparations in the various indications for which they are used.
Dosage Short-term use (healthy individuals): 0.1-1.0 g root per day in two divided doses for 15-20 days. (1) A minimum of two week with no ginseng before starting again. Doses should be taken more than two hours before or after a meal.
Long-term use (elderly individuals): 0.4-0.8 g root per day.

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Wren RC. Potter's New Cyclopedia of Botanical Drugs and Preparations (revised, Williamson WE, Evans FJ). Saffron Walden: Daniel, 1988.

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Barrow AI. Medicinal uses of ginseng and related plants in the Soviet Union: recent trends in the Soviet literature. J Enthnpharmacol 1982; 6: 339-353.

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Li TB, et al. Effects of ginsenosides, lectins and Momoridica Charantia insulin-like peptide corticosterone production by isolated rat adrenal cells. J Ethnopharmacol 1988; 92: 129-136.

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Filaretor AA, et al. Role of pituitary-adrenocortical system in body adaptation abilities. Exp Clin Endocrinol 1988; 92: 129-136.

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